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Protein kinase C and fatty acid transport protein 4 (FATP4) [144] play an important role in the increase of GLP-1 secretion and improvement in glycemic tolerance caused by oleic acid (OA), both in vivo and in vitro [145]
[24] However, an increase in ROS production can be neutralized by the antioxidant defense system, or natural antioxidants and dietary supplements, to maintain redox status
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